Resource
| Id | gene_properties/gene_scores/LGD |
|---|---|
| Type | gene_score |
| Version | 0 |
| Summary | Gene vulnerability/intolerance score based on the rare LGD variants |
| Description |
The LGD vulnerability score is described in https://pubmed.ncbi.nlm.nih.gov/26401017 and is based on relating the observed and expected numbers of ultra-rare LGD variants, where the expected number of ultra-rare LGDs in a gene is computed through a regression to the number of ultra-rare synonymous variants. The score is defined as the cumulative distribution function at the observed number of UR LGD variants of a Poisson distribution with a parameter equal to the expected number of UR LGD variants. |
| Labels |
Scores (2)
| ID | Type | Description | Histograms | Range | Summary |
|---|---|---|---|---|---|
| LGD_rank |
Gene rank after sorting by LGD vulnerability score
Small values desc: more likely to be vulnerable
Large values desc: less likely to be vulnerable
|
|
[1, 1.84e+04] |
|
|
| LGD_score |
Likelihood that a gene is vulnerable to damaging mutation
Small values desc: more likely to be vulnerable
Large values desc: less likely to be vulnerable
|
|
[1.4e-05, 1] |
|
n counts genes; sd is the population standard deviation.
Files
| Filename | Size | md5 |
|---|---|---|
| LGD.csv | 497.77 KB | 4e9f0967f510d53285a51dfc33b4d06c |
| genomic_resource.yaml | 1.37 KB | 8b52dbb3a2a2ea85475a6d523e8c1d23 |
| statistics/ |