type: gene_set_collection
id: MSigDB_curated
format: gmt
filename: c2.all.v7.5.symbols.gmt
web_label: MSigDB Pathways
web_format_str: "key| (|count|)"
histograms:
  genes_per_gene_set:
    type: number
    y_log_scale: True
  gene_sets_per_gene:
    type: number
    y_log_scale: True
meta:
  summary: |
    MSigDB (Molecular Signatures Database) gene sets derived from a variety of curated sources

  description: |
    The Curated (C2) collection of the Molecular Signatures Database (MSigDB) 
    comprises gene sets derived from canonical pathway databases (such as KEGG, 
    Reactome, and BioCarta) and from gene expression studies in the literature. 
    These sets represent well-defined biological pathways, signaling cascades, 
    and experimentally derived perturbation signatures. The C2 collection 
    enables systematic assessment of how experimental gene expression profiles 
    align with established biological knowledge.
    
    [Liberzon et al., Molecular signatures database (MSigDB) 3.0, Bioinformatics, 2011](https://academic.oup.com/bioinformatics/article/27/12/1739/257711)
    
    [Liberzon et al., The Molecular Signatures Database Hallmark Gene Set Collection, Cell Systems, 2015](https://www.cell.com/fulltext/S2405-4712(15)00218-5)

    Downloaded on: 01/28/26

    [https://data.broadinstitute.org/gsea-msigdb/msigdb/release/7.5/c2.all.v7.5.symbols.gmt](https://data.broadinstitute.org/gsea-msigdb/msigdb/release/7.5/c2.all.v7.5.symbols.gmt)