type: gene_set_collection

id: autism
format: directory
directory: AutismGeneSets
web_label: Autism Gene Sets
web_format_str: "key| (|count|): |desc"
histograms:
  genes_per_gene_set:
    type: categorical
    natural_order: True
  gene_sets_per_gene:
    type: categorical
    natural_order: True
meta:
  summary: |
    Autism gene sets derived from publications

  description: |
    This resource consolidates autism risk/candidate genes reported by multiple landmark, large-scale sequencing studies into a single curated collection for downstream annotation and enrichment analyses. The gene lists were drawn from the following widely cited publications:
  
    - [Iossifov I., et al. Low load for disruptive mutations in autism genes and their biased transmission. PNAS (2015)](https://www.pnas.org/doi/10.1073/pnas.1516376112). 
    - [Sanders S., et al. Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci. Neuron (2015)](https://pubmed.ncbi.nlm.nih.gov/26402605/). 
    - [Yuen R. K. C., et al. Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder. Nature Neuroscience (2017)](https://pubmed.ncbi.nlm.nih.gov/28263302/). 
    - [Satterstrom F. K., et al. Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism. Cell (2020)](https://pubmed.ncbi.nlm.nih.gov/31981491/). 
    - [Turner T. N., Eichler E. E., et al. Sex-Based Analysis of De Novo Variants in Neurodevelopmental Disorders. The American Journal of Human Genetics (2019)](https://pubmed.ncbi.nlm.nih.gov/31785789/).