---

type: position_score

table:
  filename: hg38.phastCons30way.bw

  # defined by score_type
  chrom:
    index: 0
  pos_begin:
    index: 1
  pos_end:
    index: 2

# score values
scores:
  - id: phastCons30way
    type: float
    desc: "The score is a number that reflects the conservation at a position."
    large_values_desc: "more conserved"
    small_values_desc: "less conserved"
    index: 3
    histogram:
      type: number
      number_of_bins: 100
      view_range:
        min: 0.0
        max: 1.0
      y_log_scale: True

default_annotation:
  - source: phastCons30way
    name: phastcons30way

meta:
  summary: |
    Conservation score based on the multiple alignment of 30 species

  description: |
    
    PhastCons score is a measure used to assess the level of evolutionary conservation of genomic sequences. This score is derived from a method called [PHAST (Phylogenetic Analysis with Space/Time models)](http://compgen.cshl.edu/phast/), which uses multiple sequence alignments and phylogenetic trees to identify conserved elements across different species. phastCons30way refers to a specific set of PhastCons conservation scores derived from a multiple sequence alignment of the genomes of 30 different species. 
    
    PhastCons scores typically range from 0 to 1. A score closer to 1 suggests high conservation, implying that the sequence has remained largely unchanged through evolution, likely due to selective pressure to maintain its function. A score closer to 0 indicates low conservation, suggesting that the sequence is less critical or more variable across species.  

    [Hubizs et al., PHAST and RPHAST: phylogenetic analysis with space/time models, Briefings in Bioinformatics 2011](https://academic.oup.com/bib/article/12/1/41/244593)

    Downloaded on: 06/04/24

    [https://hgdownload.soe.ucsc.edu/goldenPath/hg38/phastCons30way/hg38.phastCons30way.bw](https://hgdownload.soe.ucsc.edu/goldenPath/hg38/phastCons30way/hg38.phastCons30way.bw)